Distress tolerance is a focus of interest for clinical scientists and practitioners because this construct has been purported to contribute to the development and maintenance of several forms of psychopathology. The aim of the present study was to compare the effectiveness of group positive psychotherapy and psychodrama group therapy on distress tolerance of individuals with chronic pain. The study was a semi-experimental research with pre-test & post-test design with control group, and the statistical population included all individuals suffering from chronic pain who visited Pars Royal Clinic in Tehran, Iran in 2018 spring and summer, from among whom a sample of 45 persons were selected using convenience sampling method and were assigned to three groups of 15. Research tools included Iranian Distress Tolerance Scale (Simons and Gaher, 2005), Positive Psychotherapy Protocol (Rashid, 2009) and Therapeutic Psychodrama Package, and for analyzing the data ANCOVA was utilized. Research findings indicated that group positive psychotherapy was more effective than psychodrama on improving distress tolerance of individuals suffering from chronic pain (P<0.01). Based on the results, group positive psychotherapy compared to psychodrama is more effective on improving distress tolerance of individuals with chronic pain, which in turn increases the well-being of this population.