The work introduces an empirical system developed to bring happiness to the centre of business strategies. The system was tested in a Brazilian private hospital. It aims to disseminate a framework that has shown positive results in both employees’ well-being and business performance. The system was based on the Gross National Happiness Framework (GNH),, considered by the United Nations (UN) the New Economic Paradigm. Measurement tools were established to check the status of the organization at the beginning of the project. The first step was the adaptation of the GNH survey to business and cultural specificities. The survey aimed to measure the Corporate GNH Index in order to guide the actions to be implemented. It was designed a Comprehensive Happiness Program, with special emphasis on Positive Psychology interventions. In order to verify the impact, the following Indicators were chosen: Absenteeism, Turn Over, Organizational Climate, Internal Customer Satisfaction, External Customer Satisfaction, Net Promoter Score and Rentability. At the end of the first year important KPIs reached figures above the average: Internal Customer Satisfaction, External Customer Satisfaction, Net Promoter Score (Inpatient) and Net Promoter Score (Emergency Unit). It was also observed an increment in rentability.