Although there is evidence on the importance of relationships for the experience of meaning in life in the West, the Ghanaian context has not been represented. In addition, the meaning-relationality model is yet to be empirical tested from a relational perspective. The present study explored why relationships were important to a sample of urban employed Ghanaian adults with the aim of tapping into attributions of meaning. A sample of 50 participants (Mean age = 42; Female = 21) were included and thematic analysis was performed on qualitative responses to the question: “what are your most important relationships and why”. Vertical connectedness had both implicit and explicit attributions to the experience of meaning in life. Implicit attributions included reference to the “supernatural” as an existential source and defining framework for life itself. Explicit attributions pointed to “God” as provider of meaning and the lack of utility of a life without this vertical connectedness. While other forms of relationships seem to serve a wider purpose with meaning forming a small component, relationships pointing to existential concerns play a stronger role in contributing to meaning in the Ghanaian context. Research and practice could benefit from using existential-related connections in enhancing psychological well-being.