The aim of the present study was to compare the effectiveness of group positive psychotherapy and psychodrama group therapy on spiritual attitude of individuals with chronic pain because it is indicated in many researches that spirituality-oriented interventions in this population has a great effect on well-being and increase in quality of life of these folks. The study was a semi-experimental research with pre-test, post-test and follow-up design with control group, and the statistical population included all individuals suffering from chronic pain who visited Pars Royal Clinic in Tehran, Iran in 2018 spring and summer, from among whom a sample of 45 persons were selected using convenience sampling method and were assigned to three groups of 15. Research tools included Iranian Spiritual Attitude Questionnaire, Rashid’s Positive Psychotherapy Protocol and Therapeutic Psychodrama Package, and for analyzing the data analysis of covariance was utilized. Research findings indicated that group positive psychotherapy was more effective than psychodrama on improving the spiritual attitude of individuals suffering from chronic pain (P<0.01). Based on the results, group positive psychotherapy compared to psychodrama is more effective on improving the spiritual attitude of individuals with chronic pain, which in turn increases the quality of life of this population.