At the individual level, there is substantial variation in brain structure morphology and brain functions. To identify robust and replicable associations with genetic variants or psychiatric conditions large well-powered studies are required. Due to the substantial costs associated with imaging studies collaborative research strategies are becoming increasingly important. Within the context of the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium, we conduct collaborative large-scale genetic analysis of magnetic resonance imaging (MRI) scans. Our work focuses both on the discovery of genetic variants that exert lasting influences on brain structure and function and on the identification of disease correlates. Our recent findings will be discussed focusing on genetic variants influencing the morphology of cortical structures. These studies highlight the role of common genetic variation in influencing the structure of the human brain and the importance of collaboration and cooperation in advancing science.