Meaning and relational well-being are key and closely related facets of well-being. This study aimed to explore patterns of meaning and relational well-being by considering latent profiles and concomitants thereof. Patterns were investigated using, inter alia, latent profile analyses which were applied to data from diverse South African samples that completed measures of meaning and relational well-being, as well as other aspects of intrapersonal, interpersonal, and community well-being. The profiles mainly distinguished people high and low on a global well-being factor, but the existence of more specific nuances was also suggested. The intertwinedness of meaning and relational well-being was suggested and light was shed on some of the dynamics between these variables. Cultural variations emphasized the importance of taking context into account.