Background: Migrant workers’ well-being is negatively impacted by work-induced family separation. High level of close relationship quality may be associated with more perceived social support from their partners, which might facilitate migrant workers’ resilience in face of adversity and promote their life satisfaction. Method: The current study recruited 900 mainland Chinese migrant workers in Macau. Self-report data were collected. Regression analysis was used to examine the relationship between close relationship quality and life satisfaction. Bootstrapping strategy was applied to test the indirect effects of perceived social support and resilience. Results: Close relationship quality was found to be associated with life satisfaction directly and indirectly from perceived social support and resilience, after controlling for age, gender, educational level, married status, and subjective socioeconomic. Additionally, perceived social support was associated with life satisfaction indirectly via resilience. Conclusion: Our finding highlights the importance of maintaining high level of close relationship quality, increasing perception of social support, and enhancing resilience to facilitate migrant workers’ well-being.